Journal of Medicinal Chemistry
Volume 39, Issue 8 (April 12, 1996)
Copyright © 1996 American Chemical Society

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1571-1574

Conformationally Restricted TRH Analogs: A Probe for the Pyroglutamate Region Lawrence D. Rutledge, Jeffery H. Perlman, Marvin C. Gershengorn, Garland R. Marshall, and Kevin D. Moeller [Full Article - PDF]

1575-1581

Synthesis and Biological Evaluation of Naphthyldesferrithiocin Iron Chelators Raymond J. Bergeron, Jan Wiegand, Markus Wollenweber, James S. McManis, Samuel E. Algee, and Katie Ratliff-Thompson [Full Article - PDF]

1582-1588

A 5'-(Trifluoromethyl)anthracycline Glycoside: Synthesis of Antitumor-Active 7-O-(2,6-Dideoxy-6,6,6-trifluoro--L-lyxo-hexopyranosyl)adriamycinone Yasushi Takagi, Ken Nakai, Tsutomu Tsuchiya, and Tomio Takeuchi [Full Article - PDF]

1589-1600

Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors Andrew L. Hopkins, Jingshan Ren, Robert M. Esnouf, Benjamin E. Willcox, E. Yvonne Jones, Carl Ross, Tadashi Miyasaka, Richard T. Walker, Hiromichi Tanaka, David K. Stammers, and David I. Stuart [Full Article - PDF]

1601-1608

Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags Zhi-Jie Ni, Derek Maclean, Christopher P. Holmes, Martin M. Murphy, Beatrice Ruhland, Jeffrey W. Jacobs, Eric M. Gordon, and Mark A. Gallop [Full Article - PDF]

1609-1618

6- and 7-Substituted 2-[2'-(Dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones: Synthesis, Nucleophilic Displacements, Antitumor Activity, and Quantitative Structure-Activity Relationships Salah M. Sami, Robert T. Dorr, Anikó M. Sólyom, David S. Alberts, Bhashyam S. Iyengar, and William A. Remers [Full Article - PDF]

1619-1625

Lipophilic, Acid-Stable, Adenosine Deaminase-Activated Anti-HIV Prodrugs for Central Nervous System Delivery. 3. 6-Amino Prodrugs of 2'--Fluoro-2',3'-dideoxyinosine John S. Driscoll, Maqbool A. Siddiqui, Harry Ford, Jr., James A. Kelley, Jeri S. Roth, Hiroaki Mitsuya, Masatoshi Tanaka, and Victor E. Marquez [Full Article - PDF]

1626-1634

Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. Part 2. Polymerized Anionic Surfactants Derived from Amino Acids and Dipeptides A. Leydet, H. El Hachemi, B. Boyer, G. Lamaty, J. P. Roque, D. Schols, R. Snoeck, G. Andrei, S. Ikeda, J. Neyts, D. Reymen, J. Este, M. Witvrouw, and E. De Clercq [Full Article - PDF]

1635-1644

Synthesis and Cyclic GMP Phosphodiesterase Inhibitory Activity of a Series of 6-Phenylpyrazolo[3,4-d]pyrimidones Bernard Dumaître and Nerina Dodic [Full Article - PDF]

1645-1650

All-Atom Models for the Non-Nucleoside Binding Site of HIV-1 Reverse Transcriptase Complexed with Inhibitors: A 3D QSAR Approach Rick Gussio, Nagarajan Pattabiraman, Daniel W. Zaharevitz, Glen E. Kellogg, Igor A. Topol, William G. Rice, Catherine A. Schaeffer, John W. Erickson, and Stanley K. Burt [Full Article - PDF]

1651-1663

CONCERTS: Dynamic Connection of Fragments as an Approach to de Novo Ligand Design David A. Pearlman and Mark A. Murcko [Full Article - PDF]

1664-1675

Use of a Dipeptide Chemical Library in the Development of Non-Peptide Tachykinin NK3 Receptor Selective Antagonists Phil Boden, Jon M. Eden, Julie Hodgson, David C. Horwell, John Hughes, Alexander T. McKnight, Russell A. Lewthwaite, Martyn C. Pritchard, Jenny Raphy, Ken Meecham, Giles S. Ratcliffe, Nirmala Suman-Chauhan, and Geoffrey N. Woodruff [Full Article - PDF]

1676-1681

Augmentation of Human and Rat Lenticular Glutathione in Vitro by Prodrugs of -L-Glutamyl-L-cysteine Herbert T. Nagasawa, Jonathan F. Cohen, Ann M. Holleschau, and William B. Rathbun [Full Article - PDF]

1682-1691

Synthesis and Pharmacology of Highly Selective Carboxy and Phosphono Isoxazole Amino Acid AMPA Receptor Antagonists Ulf Madsen, Benny Bang-Andersen, Lotte Brehm, Inge T. Christensen, Bjarke Ebert, Inge T. S. Kristoffersen, Yolande Lang, and Povl Krogsgaard-Larsen [Full Article - PDF]

1692-1703

Design, Synthesis, and Biochemical Evaluation of N-Substituted Maleimides as Inhibitors of Prostaglandin Endoperoxide Synthases Amit S. Kalgutkar, Brenda C. Crews, and Lawrence J. Marnett [Full Article - PDF]

1704-1719

Inhibitors of Acyl CoA:Cholesterol Acyltransferase Wayne Vaccaro, Cindy Amore, Joel Berger, Robert Burrier, John Clader, Harry Davis, Martin Domalski, Tom Fevig, Brian Salisbury, and Rosy Sher [Full Article - PDF]

1720-1728

6-Substituted and 5,6-Disubstituted Derivatives of Uridine: Stereoselective Synthesis, Interaction with Uridine Phosphorylase, and in Vitro Antitumor Activity Krzysztof Felczak, Alicja K. Drabikowska, Juhani A. Vilpo, Tadeusz Kulikowski, and David Shugar [Full Article - PDF]

1729-1735

Arylacetamide-Derived Fluorescent Probes: Synthesis, Biological Evaluation, and Direct Fluorescent Labeling of Opioid Receptors in Mouse Microglial Cells An-Chih Chang, Chun C. Chao, Akira E. Takemori, Genya Gekker, Shuxian Hu, Phillip K. Peterson, and Philip S. Portoghese [Full Article - PDF]

1736-1747

Design, Synthesis, and Evaluation of Latent Alkylating Agents Activated by Glutathione S-Transferase Apparao Satyam, Michael D. Hocker, Kim A. Kane-Maguire, Amy S. Morgan, Hugo O. Villar, and Matthew H. Lyttle [Full Article - PDF]

1748-1753

Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture and May Act by the Generation of a Novel Intracellular Metabolite Christopher McGuigan, Dominique Cahard, Hendrika M. Sheeka, Erik De Clercq, and Jan Balzarini [Full Article - PDF]

1754-1754

Anti-AIDS Drug Development. Challenges, Strategies and Prospects Edited by Prem Mohan and Masanori Babi. Harwood Academic Publishers, Switzerland. 1995. x + 298 pp. 18 × 25.5 cm. ISBN 3-7186-5698-1. $85.00. Donna L. Romero [Full Article - PDF]

1754-1755

Modern Conformational Analysis: Elucidating Novel Exciting Molecular Structures By Helena Dodziuk. VCH Publishers, Inc., New York. 1995. xii + 264 pp. 16 × 24 cm. ISBN 1-56081-689-9. $99.95. William F. Bailey [Full Article - PDF]

1755-1755

Symmetry: A Basis for Synthesis Design By Tse-Lok Ho. John Wiley & Sons, Inc., New York. 1995. xv + 561 pp. 16.5 × 24 cm. ISBN 0-471-57376-0. $69.95. Robert D. Walkup [Full Article - PDF]

1756-1756

Violetta Cecchetti, Arnaldo Fravolini, Maria Cristina Lorenzini, Oriana Tabarrini, Patrizia Terni, and Tao Xin: Studies on 6-Aminoquinolones: Synthesis and Antibacterial Evaluation of 6-Amino-8-methylquinolones [Full Article - PDF]